Category Archives: Human Growth Hormone

Endocrine disruptor – Wikipedia

Chemicals that can interfere with endocrine or hormonal systems Endocrine disruptors, sometimes also referred to as hormonally active agents,[1] endocrine disrupting chemicals,[2] or endocrine disrupting compounds[3] are chemicals that can interfere with endocrine (or hormonal) systems. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders.[4] Found in many household and industrial products, endocrine disruptors "interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for development, behavior, fertility, and maintenance of homeostasis (normal cell metabolism)."[5] Any system in the body controlled by hormones can be derailed by hormone disruptors. Specifically, endocrine disruptors may be associated with the development of learning disabilities, severe attention deficit disorder, cognitive and brain development problems.[6][7][8][9] There has been controversy over endocrine disruptors, with some groups calling for swift action by regulators to remove them from the market, and regulators and other scientists calling for further study.[10] Some endocrine disruptors have been identified and removed from the market (for example, a drug called diethylstilbestrol), but it is uncertain whether some endocrine disruptors on the market actually harm humans and wildlife at the doses to which wildlife and humans are exposed

Insulin-like growth factor 1 – Wikipedia

Protein-coding gene in the species Homo sapiens 1B9G, 1GZR, 1GZY, 1GZZ, 1H02, 1H59, 1IMX, 1PMX, 1TGR, 1WQJ, 2DSR, 2GF1, 3GF1, 3LRI, 1BQT, 4XSS Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. IGF-1 is a protein that in humans is encoded by the IGF1 gene.[5][6] IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 Daltons.[7] In dogs, an ancient mutation in IGF1 is the primary cause of the toy phenotype.[8] IGF-1 is produced primarily by the liver.

The role of pituitary gland in human body – Telangana Today

Published: Published Date - 11:12 PM, Sat - 15 October 22 Hyderabad: The article is in continuation to the last article about chemical coordination and integration in the human body. Today, lets continue discussion on the functions of the pituitary gland. The information can be handy for the upcoming exams

Ribociclib Can Add Almost 1 Year to Overall Survival for Patients With Aggressive Form of Breast Cancer – Pharmacy Times

Ribociclib with endocrine therapy was found to increase the median overall survival of patients with HR+/HER2- advanced breast cancer with visceral metastases to nearly 5 years. Ribociclib (Kisqali; Novartis) was found to add nearly 1 year to overall survival (OS) in patients with aggressive hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (aBC). In a pooled exploratory analysis of the MONALEESA phase 3 program presented at the 2022 European Society of Medical Oncology Congress (ESMO), researchers found that first-line treatment with ribociclib and endocrine therapy increased the median OS by 10.6 months, compared to endocrine therapy alone.